Haloduracin α Binds the Peptidoglycan Precursor Lipid II with 2:1 Stoichiometry

  title={Haloduracin α Binds the Peptidoglycan Precursor Lipid II with 2:1 Stoichiometry},
  author={Trent J. Oman and Tania J. Lupoli and Tsung-Shing Andrew Wang and Daniel E Kahne and Suzanne Walker and Wilfred A van der Donk},
  booktitle={Journal of the American Chemical Society},
The two-peptide lantibiotic haloduracin is composed of two post-translationally modified polycyclic peptides that synergistically act on gram-positive bacteria. We show here that Halα inhibits the transglycosylation reaction catalyzed by PBP1b by binding in a 2:1 stoichiometry to its substrate lipid II. Halβ and the mutant Halα-E22Q were not able to inhibit this step in peptidoglycan biosynthesis, but Halα with its leader peptide still attached was a potent inhibitor. Combined with previous… CONTINUE READING

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