Halocynthiaxanthin and Peridinin Sensitize Colon Cancer Cell Lines to Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand

  title={Halocynthiaxanthin and Peridinin Sensitize Colon Cancer Cell Lines to Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand},
  author={Tatsushi Yoshida and Takashi Maoka and Swadesh K. Das and Kazuki Kanazawa and Mano Horinaka and Miki Wakada and Yoshiko Satomi and Hoyoku Nishino and Toshiyuki Sakai},
  journal={Molecular Cancer Research},
  pages={615 - 625}
Carotenoids are compounds contained in foods and possess anticarcinogenic activity. Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) is a promising candidate for cancer therapeutics due to its ability to induce apoptosis selectively in cancer cells. However, some tumors remain tolerant to TRAIL-induced apoptosis. Therefore, it is important to develop agents that overcome this resistance. We show, for the first time, that certain carotenoids sensitize cancer cells to TRAIL-induced… 

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