Haloarchaeal gas vesicle nanoparticles displaying Salmonella antigens as a novel approach to vaccine development.

@article{Dassarma2015HaloarchaealGV,
  title={Haloarchaeal gas vesicle nanoparticles displaying Salmonella antigens as a novel approach to vaccine development.},
  author={Priya Dassarma and Vaibhav Negi and Arjun Balakrishnan and Jae-Myung Kim and Ram Karan and Dipshikha Chakravortty and Shiladitya DasSarma},
  journal={Procedia in vaccinology},
  year={2015},
  volume={9},
  pages={16-23}
}
A safe, effective, and inexpensive vaccine against typhoid and other Salmonella diseases is urgently needed. In order to address this need, we are developing a novel vaccine platform employing buoyant, self-adjuvanting gas vesicle nanoparticles (GVNPs) from the halophilic archaeon Halobacterium sp. NRC-1, bioengineered to display highly conserved Salmonella enterica antigens. As the initial antigen for testing, we selected SopB, a secreted inosine phosphate effector protein injected by… CONTINUE READING