Haloacid induced alterations in fertility and the sperm biomarker SP22 in the rat are additive: validation of an ELISA.

@article{Kaydos2004HaloacidIA,
  title={Haloacid induced alterations in fertility and the sperm biomarker SP22 in the rat are additive: validation of an ELISA.},
  author={Emilie H Kaydos and Juan D. Suarez and Naomi L Roberts and Kathy L Bobseine and Robert Martin Zucker and John W. Laskey and Gary Robert Klinefelter},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2004},
  volume={81 2},
  pages={430-42}
}
Dibromoacetic acid (DBA) and bromochloroacetic acid (BCA) are prevalent disinfection by-products of drinking water that produce defects in spermatogenesis and fertility in adult rats. Previously we demonstrated that BCA compromises the fertility of cauda epididymal rat sperm and SP22, a sperm membrane protein that is highly correlated with the fertility of these sperm. Herein, we administered DBA and BCA, individually and in combination, to determine whether fertility and levels of SP22 on… CONTINUE READING

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