Haloacetate-induced oxidative damage to DNA in the liver of male B6C3F1 mice.

@article{Parrish1996HaloacetateinducedOD,
  title={Haloacetate-induced oxidative damage to DNA in the liver of male B6C3F1 mice.},
  author={J M Parrish and Erica Weintraub Austin and David K. Stevens and David H. Kinder and Richard J. Bull},
  journal={Toxicology},
  year={1996},
  volume={110 1-3},
  pages={103-11}
}
Brominated and chlorinated haloacetates (HAs) are by-products of drinking water disinfection. Dichloroacetate (DCA) and trichloroacetate (TCA) are hepatocarcinogenic in rodents, but the brominated analogs have received little study. Prior work has indicated that acute doses of the brominated derivatives are more potent inducers of oxidative stress and increase the 8-hydroxydeoxyguanosine (8-OH-dG) content of the nuclear DNA in the liver. Since, DCA and TCA are also known as weak peroxisome… CONTINUE READING