Halo and Pseudohalo Gold(I)-NHC Complexes Derived from 4,5-Diarylimidazoles with Excellent in Vitro and in Vivo Anticancer Activity Against HCC.

  title={Halo and Pseudohalo Gold(I)-NHC Complexes Derived from 4,5-Diarylimidazoles with Excellent in Vitro and in Vivo Anticancer Activity Against HCC.},
  author={Mianli Bian and Rong Fan and Gui-Ji Jiang and Yingxiang Wang and Yunlong Lu and Wukun Liu},
  journal={Journal of medicinal chemistry},
A series of halo and pseudohalo gold(I)-NHC complexes (NHC-Au-X) (X = Cl, Br, I, NCO, OAc) derived from 4,5-diarylimidazoles were synthesized, structurally characterized and analyzed for their biological activities. The most active iodo(1,3-diethyl-4,5-bis(4-methoxyphenyl)imidazol-2-ylidene)gold(I) (6) was at least 2-fold more cytotoxic than cisplatin and auranofin against hepatocellular carcinoma (HCC) cells. In vivo studies indicated that complex 6 exhibited considerably higher anticancer… Expand
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