Hallucinogenic drug interactions with neurotransmitter receptor binding sites in human cortex

  title={Hallucinogenic drug interactions with neurotransmitter receptor binding sites in human cortex},
  author={Pamela A. Pierce and Stephen J. Peroutka},
The binding affinities of four hallucinogenic agents were analyzed at nine neurotransmitter binding sites in human cortex. d-Lysergic acid diethylamide (d-LSD), N,N-dimethyltryptamine (DMT), 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and 1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane (DOB) display highest affinity for the recently identified “DOB binding site” labeled by 77Br-R(-)DOB. The phenalkylamines, DOI and DOB, display subnanomolar affinity for the 77Br-R(-)DOB-labeled site… CONTINUE READING
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