Hallucinogenic drug interactions with neurotransmitter receptor binding sites in human cortex

@article{Pierce1989HallucinogenicDI,
  title={Hallucinogenic drug interactions with neurotransmitter receptor binding sites in human cortex},
  author={Pamela A. Pierce and Stephen J. Peroutka},
  journal={Psychopharmacology},
  year={1989},
  volume={97},
  pages={118-122}
}

• Pamela A. Pierce, Stephen J. Peroutka
• Published 1989 in Psychopharmacology
• DOI:10.1007/BF00443425

The binding affinities of four hallucinogenic agents were analyzed at nine neurotransmitter binding sites in human cortex. d-Lysergic acid diethylamide (d-LSD), N,N-dimethyltryptamine (DMT), 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and 1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane (DOB) display highest affinity for the recently identified “DOB binding site” labeled by 77Br-R(-)DOB. The phenalkylamines, DOI and DOB, display subnanomolar affinity for the 77Br-R(-)DOB-labeled site… CONTINUE READING

View on Springer

Alternate Sources

Add to Library

Create Alert

Cite