Hallucinogenic N-Methylated Indolealkylamines in the Cerebrospinal Fluid of Psychiatric and Control Populations

@article{Corbett1978HallucinogenicNI,
  title={Hallucinogenic N-Methylated Indolealkylamines in the Cerebrospinal Fluid of Psychiatric and Control Populations},
  author={Lionel Corbett and Samuel T. Christian and Richard D. Morin and Frederick Benington and John Raymond Smythies},
  journal={British Journal of Psychiatry},
  year={1978},
  volume={132},
  pages={139 - 144}
}
The incidence and quantities of dimethyltryptamine and O-methyl-bufotenine were studied in the cerebrospinal fluid of patients suffering acute schizophrenic illnesses and in surgical and neurological control groups. Some schizophrenic patients have higher levels of both amines than do controls, though the differences in distribution did not reach statistical significance in the sample studied. The gas-chromatographic technique used is sensitive at the low picogram level. 
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45 Citations
Background Citations
7
Methods Citations
2
Results Citations
1

45 Citations

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A critical review of 69 published studies reporting the detection or detection and quantitation of these compounds in human body fluids addresses the methods applied and the criteria used in the determination of the presence of DMT, MDMT, and HDMT.
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  • 1995
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  • 1995
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References

SHOWING 1-10 OF 10 REFERENCES
Gas-liquid chromatographic separation and identification of biologically important indolealkylamines from human cerebrospinal fluid.
The biosynthesis of 5-methoxy-N,N-dimethyltryptamine in vitro.
Differentiating criteria for acute-chronic distinction in schizophrenia.
TLDR
Preadmission social functioning of the two patient groups was more similar than generally indicated by previous reserach and poor relationships with parents, friends, and opposite-sexed peers as important factors for acute patients and antisocial behavior and inability to relate to the opposite sex and others in the community as important variables for chronic patients were identified.
Diagnostic criteria for use in psychiatric research.
TLDR
Diagnostic criteria for 14 psychiatric illnesses along with the validating evidence for these diagnostic categories comes from workers outside the authors' group as well as from those within; it consists of studies of both outpatients and inpatients, of family studies, and of follow-up studies.
Blood dimethyltryptamine concentrations in psychotic disorders.
5-methoxy-N, N-dimethyltryptamine, a possible endogenous psychotoxin.
N,N-dimethyltryptamine--a possible relationship to schizophrenia?
Evi dence of dimethyltryptamine as naturally occurring transmitter in mammalian brain
  • Alabama Journal of Medical Science
  • 1976
Gas . chromatographic - mass spectrometric isotope dilution determination of N - N - dimethyltryptamine concentra tions in normals and psychiatric patients
  • Psycho pharmacologia
Identifica tion and separation of indolealkylamines by gas liquid chromatographic analysis of their heptafluoro butyryl derivatives