Hallucinogenic N-Methylated Indolealkylamines in the Cerebrospinal Fluid of Psychiatric and Control Populations

  title={Hallucinogenic N-Methylated Indolealkylamines in the Cerebrospinal Fluid of Psychiatric and Control Populations},
  author={Lionel Corbett and Samuel T. Christian and Richard D. Morin and Frederick Benington and John Raymond Smythies},
  journal={British Journal of Psychiatry},
  pages={139 - 144}
The incidence and quantities of dimethyltryptamine and O-methyl-bufotenine were studied in the cerebrospinal fluid of patients suffering acute schizophrenic illnesses and in surgical and neurological control groups. Some schizophrenic patients have higher levels of both amines than do controls, though the differences in distribution did not reach statistical significance in the sample studied. The gas-chromatographic technique used is sensitive at the low picogram level. 
Endogenous Hallucinogens in Cerebrospinal Fluid
The search for an endogenous psychotogen as a biochemical cause or biochemical indicator of schizophrenia was stimulated in 1952 when Harley-Mason, Osmond, and Smythies suggested that abnormal
Endogenous psychoactive tryptamines reconsidered: an anxiolytic role for dimethyltryptamine.
Altered consciousness states and endogenous psychoses: a common molecular pathway?
Monoamines and monoamine metabolites in brains from demented schizophrenics
The brains from 12 schizophrenic patients were investigated postmortem for their content of noradrenaline (NA), dopamine (DA), 5‐hydroxytryptamine (5‐HT), homovanillic acid (HVA), and 5‐HIAA and there was a trend towards lower means in the schizophrenics.
A critical review of reports of endogenous psychedelic N, N-dimethyltryptamines in humans: 1955-2010.
A critical review of 69 published studies reporting the detection or detection and quantitation of these compounds in human body fluids addresses the methods applied and the criteria used in the determination of the presence of DMT, MDMT, and HDMT.
Hallucinogenic Drugs in Psychiatric Research and Treatment Perspectives and Prospects
  • R. Strassman
  • Psychology, Medicine
    The Journal of nervous and mental disease
  • 1995
It is critical that human hallucinogen research in the 1990s make use of state of the art methodologies, or consensually define when modifications are required, and training and supervisory issues also must be explicitly addressed.
Human psychopharmacology of N,N-dimethyltryptamine
  • R. Strassman
  • Psychology, Biology
    Behavioural Brain Research
  • 1995
The role of serotonin in schizophrenia.
5HT dysfunction might be related to Type II, or negative syndrome, schizophrenia, and the nature of this dysfunction might involve 5HT postsynaptic receptor hypersensitivity, and it is suggested that the pharmacotherapy of schizophrenia should include a 5HT- blocking component, as well as a dopamine-blocking component.


Differentiating criteria for acute-chronic distinction in schizophrenia.
Preadmission social functioning of the two patient groups was more similar than generally indicated by previous reserach and poor relationships with parents, friends, and opposite-sexed peers as important factors for acute patients and antisocial behavior and inability to relate to the opposite sex and others in the community as important variables for chronic patients were identified.
Diagnostic criteria for use in psychiatric research.
Diagnostic criteria for 14 psychiatric illnesses along with the validating evidence for these diagnostic categories comes from workers outside the authors' group as well as from those within; it consists of studies of both outpatients and inpatients, of family studies, and of follow-up studies.
N,N-dimethyltryptamine--a possible relationship to schizophrenia?
Evi dence of dimethyltryptamine as naturally occurring transmitter in mammalian brain
  • Alabama Journal of Medical Science
  • 1976
Gas . chromatographic - mass spectrometric isotope dilution determination of N - N - dimethyltryptamine concentra tions in normals and psychiatric patients
  • Psycho pharmacologia
Identifica tion and separation of indolealkylamines by gas liquid chromatographic analysis of their heptafluoro butyryl derivatives