Hallucinogenic N-Methylated Indolealkylamines in the Cerebrospinal Fluid of Psychiatric and Control Populations

@article{Corbett1978HallucinogenicNI,
  title={Hallucinogenic N-Methylated Indolealkylamines in the Cerebrospinal Fluid of Psychiatric and Control Populations},
  author={Lionel Corbett and Samuel T. Christian and Richard D. Morin and Frederick Benington and John Raymond Smythies},
  journal={British Journal of Psychiatry},
  year={1978},
  volume={132},
  pages={139 - 144}
}
The incidence and quantities of dimethyltryptamine and O-methyl-bufotenine were studied in the cerebrospinal fluid of patients suffering acute schizophrenic illnesses and in surgical and neurological control groups. Some schizophrenic patients have higher levels of both amines than do controls, though the differences in distribution did not reach statistical significance in the sample studied. The gas-chromatographic technique used is sensitive at the low picogram level. 
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45 Citations
Background Citations
7
Methods Citations
2
Results Citations
1

45 Citations

Endogenous Hallucinogens in Cerebrospinal Fluid
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A critical review of reports of endogenous psychedelic N, N-dimethyltryptamines in humans: 1955-2010.
TLDR
A critical review of 69 published studies reporting the detection or detection and quantitation of these compounds in human body fluids addresses the methods applied and the criteria used in the determination of the presence of DMT, MDMT, and HDMT.
Hallucinogenic Drugs in Psychiatric Research and Treatment Perspectives and Prospects
  • R. Strassman
  • Psychology, Medicine
    The Journal of nervous and mental disease
  • 1995
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It is critical that human hallucinogen research in the 1990s make use of state of the art methodologies, or consensually define when modifications are required, and training and supervisory issues also must be explicitly addressed.
Human psychopharmacology of N,N-dimethyltryptamine
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  • Psychology, Biology
    Behavioural Brain Research
  • 1995
Metabolism of the hallucinogen N,N-dimethyltryptamine in rat brain homogenates.
The role of serotonin in schizophrenia.
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5HT dysfunction might be related to Type II, or negative syndrome, schizophrenia, and the nature of this dysfunction might involve 5HT postsynaptic receptor hypersensitivity, and it is suggested that the pharmacotherapy of schizophrenia should include a 5HT- blocking component, as well as a dopamine-blocking component.
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