Hallucinatory and rewarding effect of salvinorin A in zebrafish: κ-opioid and CB1-cannabinoid receptor involvement

@article{Braida2006HallucinatoryAR,
  title={Hallucinatory and rewarding effect of salvinorin A in zebrafish: $\kappa$-opioid and CB1-cannabinoid receptor involvement},
  author={Daniela Braida and Valeria Limonta and Simona Pegorini and Alessia Zani and Chiara Guerini-Rocco and Enzo Gori and Mariaelvina Sala},
  journal={Psychopharmacology},
  year={2006},
  volume={190},
  pages={441-448}
}
RationaleThe hallucinatory effect and potential abuse of salvinorin A, the major ingredient of Salvia divinorum, has not been documented in animals.ObjectiveThe effects of salvinorin A on the zebrafish (Danio rerio) model, through its swimming behavior and conditioned place preference (CPP) task, was studied.Materials and methodsSwimming activity was determined in a squared observational chamber after an i.m. treatment of salvinorin A (0.1–10 μg/kg). For the CPP test, zebrafish were given… 
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TLDR
DOB and PMA administration affected spontaneous locomotion and impaired behaviors and startle/PPI responses in mice, and the two compounds promoted hallucinatory states in zebrafish by reducing the hallucinatory score and swimming activity in hallucinogen-like states.
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