Hallmarks of Cancer: The Next Generation

  title={Hallmarks of Cancer: The Next Generation},
  author={Douglas Hanahan and Robert A Weinberg},
The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease. They include sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis. Underlying these hallmarks are genome instability, which generates the… CONTINUE READING
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