Half-life extension of a single-chain diabody by fusion to domain B of staphylococcal protein A.


Binding of a therapeutic protein to a long-circulating plasma protein can result in a strongly extended half-life. Among these plasma proteins, albumin and immunoglobulins are of special interest because of their exceptionally long half-life, which is to a great extent determined by recycling through the neonatal Fc receptor (FcRn). Many strategies have… (More)
DOI: 10.1093/protein/gzr061


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