Half-Unit Insulin Pens: Disease Management in Patients With Diabetes Who Are Sensitive to Insulin.


BACKGROUND Insulin pens represent a significant technological advancement in diabetes management. While the vast majority have been designed with 1U-dosing increments, improved accuracy and precision facilitated by half-unit increments may be particularly significant in specific patients who are sensitive to insulin. These include patients with low insulin requirements and in those requiring more precise dose adjustments, such as the pediatric patient population. This review summarized functional characteristics of insulin half-unit pens (HUPs) and their effect on user experience. METHODS The literature search was restricted to articles published in English between January 1, 2000, and January 1, 2015. A total of 17 publications met the set criteria and were included in the review. RESULTS Overall, studies outlined characteristics for 4 insulin HUPs. Based on their functionality, the pens were generally similar and all met the ISO 11608-1 criteria for accuracy. However, some had specific advantageous features in terms of size, weight, design, dialing torque, and injection force. Although limited, the currently available user preference studies in children and adolescents with diabetes and their carers suggest that the selection of an HUP is likely to be influenced by a combination of factors such as these, in addition to the prescribed insulin and dosing regimen. CONCLUSIONS Insulin HUPs are likely to be a key diabetes management tool for patients who are sensitive to insulin; specific pen features may further advance diabetes management in these populations.

DOI: 10.1177/1932296816679180

Cite this paper

@article{Klonoff2017HalfUnitIP, title={Half-Unit Insulin Pens: Disease Management in Patients With Diabetes Who Are Sensitive to Insulin.}, author={David C. Klonoff and Irina Nayberg and Udo Stauder and Hamid Oualali and Catherine Domenger}, journal={Journal of diabetes science and technology}, year={2017}, volume={11 3}, pages={623-630} }