Halenaquinone inhibits RANKL-induced osteoclastogenesis.


Halenaquinone was isolated from the marine sponge Petrosia alfiani as an inhibitor of osteoclastogenic differentiation of murine RAW264 cells. It inhibited the RANKL (receptor activator of nuclear factor-κB ligand)-induced upregulation of TRAP (tartrate-resistant acid phosphatase) activity as well as the formation of multinuclear osteoclasts. In addition, halenaquinone substantially suppressed RANKL-induced IκB degradation and Akt phosphorylation. Thus, these results suggest that halenaquinone inhibits RANKL-induced osteoclastogenesis at least by suppressing the NF-κB and Akt signaling pathways.

DOI: 10.1016/j.bmcl.2014.09.043

Cite this paper

@article{Tsukamoto2014HalenaquinoneIR, title={Halenaquinone inhibits RANKL-induced osteoclastogenesis.}, author={Sachiko Tsukamoto and Tomoharu Takeuchi and Tetsuro Kawabata and Hikaru Kato and Michiko Yamakuma and Kanae Matsuo and Ahmed H El-Desoky and Fitje Losung and Remy Emile Petrus Mangindaan and Nicole Joy de Voogd and Yoichiro Arata and Hideyoshi Yokosawa}, journal={Bioorganic & medicinal chemistry letters}, year={2014}, volume={24 22}, pages={5315-7} }