Halenaquinone inhibits RANKL-induced osteoclastogenesis.

Abstract

Halenaquinone was isolated from the marine sponge Petrosia alfiani as an inhibitor of osteoclastogenic differentiation of murine RAW264 cells. It inhibited the RANKL (receptor activator of nuclear factor-κB ligand)-induced upregulation of TRAP (tartrate-resistant acid phosphatase) activity as well as the formation of multinuclear osteoclasts. In addition, halenaquinone substantially suppressed RANKL-induced IκB degradation and Akt phosphorylation. Thus, these results suggest that halenaquinone inhibits RANKL-induced osteoclastogenesis at least by suppressing the NF-κB and Akt signaling pathways.

DOI: 10.1016/j.bmcl.2014.09.043

Cite this paper

@article{Tsukamoto2014HalenaquinoneIR, title={Halenaquinone inhibits RANKL-induced osteoclastogenesis.}, author={Sachiko Tsukamoto and Tomoharu Takeuchi and Tetsuro Kawabata and Hikaru Kato and Michiko Yamakuma and Kanae Matsuo and Ahmed H El-Desoky and Fitje Losung and Remy Emile Petrus Mangindaan and Nicole Joy de Voogd and Yoichiro Arata and Hideyoshi Yokosawa}, journal={Bioorganic & medicinal chemistry letters}, year={2014}, volume={24 22}, pages={5315-7} }