Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism.

@article{Kathiriya2004HairyrelatedTF,
  title={Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism.},
  author={Irfan S. Kathiriya and Isabelle N King and Masao Murakami and Masayo Nakagawa and John M. Astle and Kelly A. Gardner and Robert D. Gerard and Eric N Olson and Deepak Srivastava and Osamu Nakagawa},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 52},
  pages={54937-43}
}
Combinatorial actions of transcription factors in multiprotein complexes dictate gene expression profiles in cardiac development and disease. The Hairy-related transcription factor (HRT) family of basic helix-loop-helix proteins is composed of transcriptional repressors highly expressed in the cardiovascular system. However, it has remained unclear whether HRT proteins modulate gene expression driven by cardiac transcriptional activators. Here, we have shown that HRT proteins inhibit cardiac… CONTINUE READING

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unpublished observation. HRT Inhibits GATA-dependent Cardiac Gene Expression

  • Y. S. Dai, B. E. Markham
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