Hairy cell leukemia associated with large granular lymphocyte leukemia: immunologic and genomic study, effect of interferon treatment.

@article{Marolleau1988HairyCL,
  title={Hairy cell leukemia associated with large granular lymphocyte leukemia: immunologic and genomic study, effect of interferon treatment.},
  author={Jean Pierre Marolleau and Tawfik Henni and Ph Gaulard and Jean Pierre Le Cou{\'e}dic and M. F. Gourdin and Marine Divin{\'e} and Alex Katz and Michel Tulliez and M. Goossens and Felix Robles Dy Reyes},
  journal={Blood},
  year={1988},
  volume={72 2},
  pages={655-60}
}
The authors describe a patient who presented an association of hairy cell leukemia (HCL) and large granular lymphocyte (LGL) leukemia. An eventual relationship between these two rare entities is analyzed. Hairy cells (HCs) were present in the blood, bone marrow, and spleen. An excess of LGLs was found only in the blood and bone marrow. After splenectomy the patient received an alpha 2-interferon (alpha 2-IFN) treatment. The HCs surface phenotype was mu+delta+kappa+, CD20+, and CD25+. The LGLs… CONTINUE READING
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