Hairy cell leukemia: at the crossroad of somatic mutation and isotype switch.

@article{Forconi2004HairyCL,
  title={Hairy cell leukemia: at the crossroad of somatic mutation and isotype switch.},
  author={Francesco Forconi and Surinder Singh Sahota and Donatella Raspadori and Micaela Ippoliti and Gavin Babbage and Francesco Lauria and Freda K Stevenson},
  journal={Blood},
  year={2004},
  volume={104 10},
  pages={
          3312-7
        }
}
Hairy cell leukemia (HCL) commonly expresses multiple immunoglobulin isotypes, a feature rare in other B-cell malignancies or in normal B cells. In HCL, there is no phenotypic evidence for subpopulations, and single cells from one previous case contained transcripts for several isotypes. This raises the questions of the differentiation status of the cell of origin and of posttransformation events. We have investigated 9 cases, all expressing multiple immunoglobulin isotypes. Multiple tumor… 
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