Hairy Cell Leukemia Preferentially Expresses the IgG 3-Subclass

  title={Hairy Cell Leukemia Preferentially Expresses the IgG 3-Subclass},
  author={Hanneke C Kluin-Nelemans and Mark M. Krouwels and Joop and Jansen and Klasien Dijkstra and Maarten J. D. van Tol and Gerard J. den Ottolander and Enno J. Dreef and Philip M. Kluin},
A I R Y CELL LEUKEMIA (HCL) is a rare form of H chronic lymphocytic leukemia characterized by splenomegaly, pancytopenia, and neoplastic mononuclear cells in the blood, bone marrow, and spleen.' These cells are most likely derived from mature B-lymphocytes, as demonstrated by the presence of surface immunoglobulins (Ig), Ig-gene rearrangements, and B-cell-specific antigens. '~~ Hairy cells strongly express Fcy receptors that easily bind extrinsic IgG.4 Therefore, the co-expression of IgG with… CONTINUE READING