Hairpin and parallel quartet structures for telomeric sequences.

  title={Hairpin and parallel quartet structures for telomeric sequences.},
  author={P Balagurumoorthy and Samir K. Brahmachari and D. Mohanty and Manju Bansal and Viswanathan Sasisekharan},
  journal={Nucleic acids research},
  volume={20 15},
The role of thymine residues in the formation of G-quartet structures for telomeric sequences has been investigated using model oligonucleotides of the type d(G4TnG4), with n = 1-4. Sequences d(G4T3G4) and d(G4T4G4) adopt a G-quartet structure formed by hairpin dimerization in 70 mM NaCl as judged by a characteristic circular dichroism signature with a 295 nm positive and 265 nm negative bands while d(G4TG4) adopts a parallel G-quartet structure like d(G12) which exhibits a strong positive band… CONTINUE READING


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