Hairbulb tyrosinase activity in oculocutaneous albinism

  title={Hairbulb tyrosinase activity in oculocutaneous albinism},
  author={Richard L. King and Carl Witkop},
HUMAN oculocutaneous albinism (OCA), characterised by hypopigmentation of skin, hair and eyes, represents a heterogeneous group of at least four distinct autosomal recessive disorders1,2. Tyrosinase-negative OCA and tyrosinase-positive OCA are the two most common forms and can be separated by genetic and clinical features1. Tyrosinase-negative albinos have no obvious pigment in their skin, hair or eyes, and their plucked hairbulbs form no visible pigment after prolonged incubation in L-tyrosine… CONTINUE READING