Hair loss and defective T- and B-cell function in mice lacking ORAI1.

@article{Gwack2008HairLA,
  title={Hair loss and defective T- and B-cell function in mice lacking ORAI1.},
  author={Yousang Gwack and Sonal Srikanth and Masatsugu Oh-hora and Patrick G. Hogan and Edward D. Lamperti and Megumi Yamashita and Curtis Gelinas and Daniel S. Neems and Yoshiyuki Sasaki and Stefan Feske and Murali Prakriya and Klaus Rajewsky and Anjana Rao},
  journal={Molecular and cellular biology},
  year={2008},
  volume={28 17},
  pages={
          5209-22
        }
}
ORAI1 is a pore subunit of the store-operated Ca(2+) release-activated Ca(2+) (CRAC) channel. To examine the physiological consequences of ORAI1 deficiency, we generated mice with targeted disruption of the Orai1 gene. The results of immunohistochemical analysis showed that ORAI1 is expressed in lymphocytes, skin, and muscle of wild-type mice and is not expressed in Orai1(-/-) mice. Orai1(-/-) mice with the inbred C57BL/6 background showed perinatal lethality, which was overcome by crossing… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 122 CITATIONS, ESTIMATED 37% COVERAGE

Downregulation of Orai1 expression in the airway alleviates murine allergic rhinitis

  • Experimental & Molecular Medicine
  • 2012
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

The STIM-Orai Pathway: Orai, the Pore-Forming Subunit of the CRAC Channel.

  • Advances in experimental medicine and biology
  • 2017
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

The functions of store-operated calcium channels.

  • Biochimica et biophysica acta. Molecular cell research
  • 2017
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

SOCE and cancer: Recent progress and new perspectives

  • International journal of cancer
  • 2016
VIEW 10 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Ion channels in innate and adaptive immunity.

  • Annual review of immunology
  • 2015
VIEW 6 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2008
2019

CITATION STATISTICS

  • 19 Highly Influenced Citations

  • Averaged 7 Citations per year from 2017 through 2019