Hair keratin KRT81 is expressed in normal and breast cancer cells and contributes to their invasiveness.

@article{Nanashima2017HairKK,
  title={Hair keratin KRT81 is expressed in normal and breast cancer cells and contributes to their invasiveness.},
  author={Naoki Nanashima and Kayo Horie and Toshiyuki Yamada and Takeshi Shimizu and Shigeki Tsuchida},
  journal={Oncology reports},
  year={2017},
  volume={37 5},
  pages={
          2964-2970
        }
}
Keratins are fibrous proteins. Hair keratins constitute hard structures such as the hair and nails, and cytokeratins have been used as markers of breast carcinoma. However, the expression and function of full-size hair keratin genes have not been previously demonstrated in breast cancer. We investigated the expression of the hair keratin, KRT81, and its function in human breast cancer and normal mammary epithelial cells. Western blotting showed full size 55-kDa KRT81 expression in the human… 
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High expression of keratin 6C is associated with poor prognosis and accelerates cancer proliferation and migration by modulating epithelial–mesenchymal transition in lung adenocarcinoma
TLDR
Depletion of KRT6C suppressed A549 cell proliferation, migration and invasion, which might be achieved by regulating EMT, and KRT 6C is identified as a potential therapeutic target for LUAD.
KRT81 Knockdown Inhibits Malignant Progression of Melanoma Through Regulating Interleukin-8.
TLDR
Findings indicate that downregulation of KRT81 could inhibit progression of melanoma by regulating IL-8 and represents a potential therapeutic target for melanoma therapy.
Combined tumor epithelial and stromal histopathology with keratin 81 expression predicts prognosis for pancreatic ductal adenocarcinoma.
TLDR
Combined tumor epithelial and stromal histopathology with keratin 81 expression is suggested to be useful to predict prognosis of PDAC.
Gene Expression Difference Between Primary and Metastatic Renal Cell Carcinoma Using Patient-Derived Xenografts
TLDR
The results prove that the PDX is a great research model for metastatic tumors since it preserved the essences for tumor metastasis and justify the applications of PDX in metastatic tumor studies.
In-silico analysis of differentially expressed genes and their regulating microRNAs involved in lymph node metastasis in invasive breast carcinoma
TLDR
In-silico survival and expression analyses revealed six candidate genes and 83 miRNAs, which may be potential diagnostic markers and therapeutic targets in BC patients and miR-155-5p shows promise as it targeted five important hub genes related to lymph-node metastasis.
In-Silico Analysis of Differentially Expressed Genes and Their Regulating microRNA Involved in Lymph Node Metastasis in Invasive Breast Carcinoma
TLDR
Six candidate hub genes are found to be significantly associated with nodal metastasis and overall survival, and 83 MicroRNA (miRNAs) which may be potential diagnostic markers and therapeutic targets in BC patients are revealed.
Comprehensive Transcriptome and Pathway Analyses Revealed Central Role for Fascin in Promoting Triple-Negative Breast Cancer Progression
TLDR
Finn ShRNA was used to generate stable fascin knockdown (FSCN1KD) in the MDA-MB-231 TNBC cell line and comprehensive mRNA and miRNA transcriptome analysis confirmed fascin’s role in promoting TNBC progression, and identified a novel opportunity for therapeutic interventions via targeting those F SCN1-related transcripts.
Metalloproteomics analysis in human mammary cell lines treated with inorganic mercury.
Transcriptome Analysis of the Inhibitory Effect of Sennoside A on the Metastasis of Hepatocellular Carcinoma Cells
TLDR
This study treated two HCC cell lines with SA and found that SA selectively inhibited the growth of HCC cells by proliferation assay and confirmed that the downregulation of KRT7 and KRT81 could inhibit HCC metastasis.
A Polymorphism at the microRNA Binding Site in the 3' Untranslated Region of KRT81 Is Associated with Breast Cancer.
TLDR
The data demonstrated that the K RT81 expressional change modulated by rs3660 miR-SNP could modify the carcinogenesis of BC, thereby KRT81 would be a new target for BC treatment.
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