Hair follicles' transit-amplifying cells govern concurrent dermal adipocyte production through Sonic Hedgehog.

@article{Zhang2016HairFT,
  title={Hair follicles' transit-amplifying cells govern concurrent dermal adipocyte production through Sonic Hedgehog.},
  author={Bing Zhang and Pai-Chi Tsai and Meryem Gonzalez-Celeiro and Oliver Chung and Benjamin Boumard and Carolina N. L. R. Perdigoto and Elena Ezhkova and Ya-chieh Hsu},
  journal={Genes & development},
  year={2016},
  volume={30 20},
  pages={2325-2338}
}
Growth and regeneration of one tissue within an organ compels accommodative changes in the surrounding tissues. However, the molecular nature and operating logic governing these concurrent changes remain poorly defined. The dermal adipose layer expands concomitantly with hair follicle downgrowth, providing a paradigm for studying coordinated changes of surrounding lineages with a regenerating tissue. Here, we discover that hair follicle transit-amplifying cells (HF-TACs) play an essential role… CONTINUE READING
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