Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis.

Abstract

Hair thinning and loss are prominent aging phenotypes but have an unknown mechanism. We show that hair follicle stem cell (HFSC) aging causes the stepwise miniaturization of hair follicles and eventual hair loss in wild-type mice and in humans. In vivo fate analysis of HFSCs revealed that the DNA damage response in HFSCs causes proteolysis of type XVII… (More)
DOI: 10.1126/science.aad4395

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