Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis

@article{Matsumura2016HairFA,
  title={Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis},
  author={Hiroyuki Matsumura and Yasuaki Mohri and Nguyen Thanh Binh and Hironobu Morinaga and Makoto Fukuda and Mayumi Ito and Sotaro Kurata and Jan H. J. Hoeijmakers and Emi K. Nishimura},
  journal={Science},
  year={2016},
  volume={351}
}
Quiescent and aging hair follicle stem cells Stem cells enable normal cell homeostasis, but they also exist in a quiescent state, ready to proliferate and differentiate after tissue damage. Now, two studies reveal features of stem cells in the hair follicle, an epithelial mini-organ of the skin that is responsible for hair growth and recycling (see the Perspective by Chuong and Lei). Wang et al. found that the Foxc1 transcription factor is induced in activated hair follicle stem cells, which in… 

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References

SHOWING 1-10 OF 90 REFERENCES

Nfatc1 orchestrates aging in hair follicle stem cells

It is shown that aged hair follicle SCs (HFSCs) in mice exhibit enhanced resting and abbreviated growth phases and are delayed in response to tissue-regenerating cues, providing unique insights into how skin SCs age.

Capturing and profiling adult hair follicle stem cells

It is shown that bulge cells in adult mice generate all epithelial cell types within the intact follicle and hair during normal hair follicle cycling and provide potential targets for the treatment of hair loss and other disorders of skin and hair.

Hair follicle stem cells provide a functional niche for melanocyte stem cells.

Regenerative hair waves in aging mice and extra-follicular modulators Follistatin, Dkk1 and Sfrp4

An excitable medium model is presented to simulate the cycling behavior in aging mice and how the inter-organ macro-environment can regulate the aging process by integrating both “activator” and “inhibitor” signals is illustrated.

Epithelial stem cells: a folliculocentric view.

Lineage analysis demonstrated that all epithelial layers within the adult follicle and hair originated from bulge cells, and Bulge cells maintain their stem cell characteristics after propagation in vitro, thus ultimately they may be useful for tissue engineering applications.

Architectural Niche Organization by LHX2 is Linked to Hair Follicle Stem Cell Function

It is concluded that architectural organization of the HF-SC niche by transcription factor LHX2 plays a critical role in HF- SC behavior and that niche organization underlies the requirement for LHx2 in hair follicle structure and function.

β-Catenin Activation Regulates Tissue Growth Non–Cell Autonomously in the Hair Stem Cell Niche

A mechanism by which Wnt/β-catenin signaling controls stem cell–dependent tissue growth non–cell autonomously is demonstrated and advances the understanding of the mechanisms that drive coordinated regeneration.

mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging.

Enrichment for living murine keratinocytes from the hair follicle bulge with the cell surface marker CD34.

This work is the first to demonstrate that CD34 is a specific marker of bulge cell keratinocytes in the cutaneous epithelium, potentially providing a tool for the study of carcinogen target cells, gene therapy, and tissue engineering applications.
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