Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis

  title={Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis},
  author={Hiroyuki Matsumura and Yasuaki Mohri and Nguyen Thanh Binh and Hironobu Morinaga and Makoto Fukuda and Mayumi Ito and Sotaro Kurata and Jan H. J. Hoeijmakers and Emi K. Nishimura},
Hair thinning and loss are prominent aging phenotypes but have an unknown mechanism. We show that hair follicle stem cell (HFSC) aging causes the stepwise miniaturization of hair follicles and eventual hair loss in wild-type mice and in humans. In vivo fate analysis of HFSCs revealed that the DNA damage response in HFSCs causes proteolysis of type XVII collagen (COL17A1/BP180), a critical molecule for HFSC maintenance, to trigger HFSC aging, characterized by the loss of stemness signatures and… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 85 references

Deschene et al . , b - Catenin activation regulates tissue growth non - cell autonomously in the hair stem cell niche

M. Qin Giangreco, J. E. Pintar, F. M. Watt
Science • 2014

The phosphoinositide 3-kinase decides

S. Laval et al., Dual roles of hemidesmosomal proteins in the pancreatic epithelium
Oncogene 33, 1934–1944 • 2014
View 1 Excerpt

b-Catenin activation regulates tissue growth non-cell autonomously in the hair stem cell niche

E. R. Deschene
Science 343, • 2014

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