Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis

@article{Matsumura2016HairFA,
  title={Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis},
  author={Hiroyuki Matsumura and Yasuaki Mohri and Nguyễn Thị Thanh B{\`i}nh and Hironobu Morinaga and Makoto Fukuda and Mayumi Ito and Sotaro Kurata and Jan H. J. Hoeijmakers and Emi K. Nishimura},
  journal={Science},
  year={2016},
  volume={351}
}
Quiescent and aging hair follicle stem cells Stem cells enable normal cell homeostasis, but they also exist in a quiescent state, ready to proliferate and differentiate after tissue damage. Now, two studies reveal features of stem cells in the hair follicle, an epithelial mini-organ of the skin that is responsible for hair growth and recycling (see the Perspective by Chuong and Lei). Wang et al. found that the Foxc1 transcription factor is induced in activated hair follicle stem cells, which in… Expand
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Hair follicle stem cells provide a functional niche for melanocyte stem cells.
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Collagen XVII (COL17A1/BP180/BPAG2), a hemidesmosomal transmembrane collagen, is highly expressed in hair follicle stem cells (HFSCs) and is required for the maintenance not only of HFSCs but also of melanocyte stem cells(MSCs), which do not express Col17a1 but directly adhere to HF SCs. Expand
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