Hair cycle regulation of Hedgehog signal reception.

@article{Oro2003HairCR,
  title={Hair cycle regulation of Hedgehog signal reception.},
  author={Anthony E Oro and Kay Higgins},
  journal={Developmental biology},
  year={2003},
  volume={255 2},
  pages={
          238-48
        }
}
Proper patterning of self-renewing organs, like the hair follicle, requires exquisite regulation of growth signals. Sonic hedgehog (Shh) signaling in skin controls the growth and morphogenesis of hair follicle epithelium in part through regulating the Gli transcription factors. While ectopic induction of Shh target genes leads to hair follicle tumors, such as basal cell carcinomas, how Shh signaling normally functions during the cyclic process of hair development is unknown. Here, we show that… CONTINUE READING
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