Hair cells use active zones with different voltage dependence of Ca2+ influx to decompose sounds into complementary neural codes.

@article{Ohn2016HairCU,
  title={Hair cells use active zones with different voltage dependence of Ca2+ influx to decompose sounds into complementary neural codes.},
  author={Tzu-Lun Ohn and Mark A Rutherford and Zhizi Jing and Sangyong Jung and Carlos J Duque-Afonso and Gerhard Hoch and Maria Magdalena Picher and Anja Scharinger and Nicola Strenzke and Tobias Moser},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2016},
  volume={113 32},
  pages={E4716-25}
}
For sounds of a given frequency, spiral ganglion neurons (SGNs) with different thresholds and dynamic ranges collectively encode the wide range of audible sound pressures. Heterogeneity of synapses between inner hair cells (IHCs) and SGNs is an attractive candidate mechanism for generating complementary neural codes covering the entire dynamic range. Here, we quantified active zone (AZ) properties as a function of AZ position within mouse IHCs by combining patch clamp and imaging of presynaptic… CONTINUE READING
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