Hair cell regeneration in the bird cochlea following noise damage or ototoxic drug damage

  title={Hair cell regeneration in the bird cochlea following noise damage or ototoxic drug damage},
  author={Douglas Allen Cotanche and Kenneth H. Lee and Jennifer S Stone and Daniel Picard},
  journal={Anatomy and Embryology},
Hair cells are sensory cells that transduce motion into neural signals. In the cochlea, they are used to detect sound waves in the environment and turn them into auditory signals that can be processed in the brain. Hair cells in the cochlea of birds and mammals were thought to be produced only during embryogenesis and, once made, they were expected to last throughout the lifetime of the animal. Thus, any loss of hair cells due to trauma or disease was thought to lead to permanent impairment of… 

Cell- and gene-therapy approaches to inner ear repair.

This review summarizes the various routes that have been explored, ranging from the genetic modification of endogenous cells remaining in the inner ear in order to promote their transdifferentiation, to the implantation of exogenous stem or progenitor cells and their subsequent differentiation within the host tissue.

Hair cell regeneration in the chick inner ear following acoustic trauma: ultrastructural and immunohistochemical studies

Results indicate that, after acoustic trauma, the supporting cells divide and differentiate into new short hair cells via spindle-shaped hair cells, and it is suggested that b-FGF is related to the proliferation of the Supporting cells and the extension of the nerve fibers.

Recovery of Function in the Avian Auditory System After Ototrauma

The contribution of regenerated hair cells to the restoration of auditory function is not fully understood, and depends on the ototraumatic events that caused inner ear damage and hair cell destruction.

Differential expression of unconventional myosins in apoptotic and regenerating chick hair cells confirms two regeneration mechanisms

Two separate mechanisms were observed during hair cell regeneration, a 4–5‐fold increase in the labeling intensity of both myosins and a redistribution of myosin VI into the stereocilia bundle, concurrent with ejection, which is critical for normal hair cell formation and function.

Towards gene therapy for deafness

This review provides an overview of recent findings concerning the possibility to prevent apoptosis in auditory cells and shows the current knowledge on the molecular mechanisms involved in the potential regenerative behavior of these cells and the progress of gene therapy to prevent deafness noise‐induced.

The Transcriptome of Utricle Hair Cell Regeneration in the Avian Inner Ear

The first comprehensive transcriptome (by mRNA-Seq) of hair cell regeneration in the chick utricle is presented and many surprising new components and dynamic expression patterns, particularly within NOTCH signaling are described.

Ultrastructural analysis of aminoglycoside‐induced hair cell death in the zebrafish lateral line reveals an early mitochondrial response

Results indicate that perturbation of the mitochondrion is an early, central event in aminoglycoside‐induced damage, and Quantitation of the types of alterations observed indicated that mitochondrial defects appear earlier and more predominantly than other structural alterations.



Evidence for supporting cell mitosis in response to acoustic trauma in the avian inner ear

  • Y. Raphael
  • Biology, Medicine
    Journal of neurocytology
  • 1992
It is suggested that supporting cells participate in scar formation during hair cell degeneration, and produce new cells for regeneration after acoustic trauma in birds.

Synchronization of hair cell regeneration in the chick cochlea following noise damage.

This study exposed 7-to 15-day-old chicks to a 1500 Hz pure tone at 120 dB SPL for 4, 12, and 24 hours and examined the recovering cochlear epithelium with scanning electron microscopy to determine when regenerated hair cells were first identifiable.

Reorganization of the chick basilar papilla after acoustic trauma

  • Y. Raphael
  • Biology
    The Journal of comparative neurology
  • 1993
The results suggest that supporting cells may play an important role in maintenance and repair of the traumatized basilar papilla and raise the possibility that production of new hair cells is not dependent on hair cell loss in the immediate vicinity.

Hair cell regeneration in the chicken cochlea following aminoglycoside toxicity

Hair Cell Loss and Regeneration after Exposure to Intense Sound in Neonatal Chicks

Hair-cell restoration after severe acoustic injury from intense sound exposure in the neonatal ear is demonstrated and can be recognized by the disorganization of hair cells in the previously injured area.

Hair cell regeneration after streptomycin toxicity in the avian vestibular epithelium

The results show that the chicken vestibular sensory epithelium is capable of regenerating hair cells after severe damage, and the epithelia is incapable of complete anatomical recovery.

Hair cell damage produced by acoustic trauma in the chick cochlea