Hair cell regeneration in the bird cochlea following noise damage or ototoxic drug damage

@article{Cotanche2004HairCR,
  title={Hair cell regeneration in the bird cochlea following noise damage or ototoxic drug damage},
  author={Douglas A. Cotanche and Kenneth H. Lee and Jennifer S Stone and Daniel Picard},
  journal={Anatomy and Embryology},
  year={2004},
  volume={189},
  pages={1-18}
}
Hair cells are sensory cells that transduce motion into neural signals. In the cochlea, they are used to detect sound waves in the environment and turn them into auditory signals that can be processed in the brain. Hair cells in the cochlea of birds and mammals were thought to be produced only during embryogenesis and, once made, they were expected to last throughout the lifetime of the animal. Thus, any loss of hair cells due to trauma or disease was thought to lead to permanent impairment of… Expand
View on Springer
ncbi.nlm.nih.gov
62 Citations
Highly Influential Citations
1
Background Citations
21
Methods Citations
1
Results Citations
2

62 Citations

Citation Type

Citation Type

Cell- and gene-therapy approaches to inner ear repair.
TLDR
This review summarizes the various routes that have been explored, ranging from the genetic modification of endogenous cells remaining in the inner ear in order to promote their transdifferentiation, to the implantation of exogenous stem or progenitor cells and their subsequent differentiation within the host tissue. Expand
Hair cell regeneration in the chick inner ear following acoustic trauma: ultrastructural and immunohistochemical studies
TLDR
Results indicate that, after acoustic trauma, the supporting cells divide and differentiate into new short hair cells via spindle-shaped hair cells, and it is suggested that b-FGF is related to the proliferation of the Supporting cells and the extension of the nerve fibers. Expand
Recovery of Function in the Avian Auditory System After Ototrauma
TLDR
The contribution of regenerated hair cells to the restoration of auditory function is not fully understood, and depends on the ototraumatic events that caused inner ear damage and hair cell destruction. Expand
Avian brainstem neurogenesis is stimulated during cochlear hair cell regeneration
TLDR
Results in NM indicate the avian auditory system is capable of Regenerating brainstem auditory neurons in addition to the previously well-established capability of regenerating cochlear hair cells in response to ototoxic injury. Expand
Differential expression of unconventional myosins in apoptotic and regenerating chick hair cells confirms two regeneration mechanisms
TLDR
Two separate mechanisms were observed during hair cell regeneration, a 4–5‐fold increase in the labeling intensity of both myosins and a redistribution of myosin VI into the stereocilia bundle, concurrent with ejection, which is critical for normal hair cell formation and function. Expand
Towards gene therapy for deafness
TLDR
This review provides an overview of recent findings concerning the possibility to prevent apoptosis in auditory cells and shows the current knowledge on the molecular mechanisms involved in the potential regenerative behavior of these cells and the progress of gene therapy to prevent deafness noise‐induced. Expand
Regeneration and replacement in the vertebrate inner ear.
TLDR
Current research efforts are focusing on gene manipulation, gene therapy and stem cell transplantation for repairing or replacing damaged mammalian cochlear hair cells, which could lead to therapies for treating deafness in humans. Expand
The Transcriptome of Utricle Hair Cell Regeneration in the Avian Inner Ear
TLDR
The first comprehensive transcriptome (by mRNA-Seq) of hair cell regeneration in the chick utricle is presented and many surprising new components and dynamic expression patterns, particularly within NOTCH signaling are described. Expand
Feathers and fins: Non-mammalian models for hair cell regeneration
TLDR
Studies on hair cell regeneration in the chicken and the zebrafish are summarized, specific advantages of each model are discussed, and future directions for the use of non-mammalian models in understanding hair cell Regeneration are proposed. Expand
Regulated Reprogramming in the Regeneration of Sensory Receptor Cells
TLDR
The current state of knowledge of regeneration in the specialized sense organs in both nonmammalian vertebrates and mammals is summarized and possible areas where new advances in regenerative medicine might provide approaches to successfully stimulate sensory receptor cell regeneration are discussed. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 119 REFERENCES
Evidence for supporting cell mitosis in response to acoustic trauma in the avian inner ear
  • Y. Raphael
  • Biology, Medicine
  • Journal of neurocytology
  • 1992
TLDR
It is suggested that supporting cells participate in scar formation during hair cell degeneration, and produce new cells for regeneration after acoustic trauma in birds. Expand
Changes in the acoustic nerve after hair cell regeneration
TLDR
It would appear that some degeneration of afferent terminals takes place prior to final innervation of new hair cells in the newly repopulated sensory epithelium, suggesting that regenerated hair cells are likely to receive neural innervation. Expand
Possible precursors of regenerated hair cells in the avian cochlea following acoustic trauma
TLDR
Examination of animals in short survival groups suggest that two precursor populations for regenerating hair cells may exist, and cuboidal or hyaline epithelial cells appear to serve as the precursor cell population for the regeneration of both hair cells and supporting cells. Expand
Synchronization of hair cell regeneration in the chick cochlea following noise damage.
TLDR
This study exposed 7-to 15-day-old chicks to a 1500 Hz pure tone at 120 dB SPL for 4, 12, and 24 hours and examined the recovering cochlear epithelium with scanning electron microscopy to determine when regenerated hair cells were first identifiable. Expand
Reorganization of the chick basilar papilla after acoustic trauma
  • Y. Raphael
  • Biology, Medicine
  • The Journal of comparative neurology
  • 1993
TLDR
The results suggest that supporting cells may play an important role in maintenance and repair of the traumatized basilar papilla and raise the possibility that production of new hair cells is not dependent on hair cell loss in the immediate vicinity. Expand
Hair cell regeneration in the chicken cochlea following aminoglycoside toxicity
TLDR
Results show that the restoration of hair cell number following aminoglycoside toxicity results from the production of new cells by mitosis, similar to developing auditory hair cells in avian embryos. Expand
Regeneration of hair cell stereociliary bundles in the chick cochlea following severe acoustic trauma
Examination of pure-tone acoustic damage in the chick cochlea revealed a significant amount of hair cell recovery over a 10 day period following the exposure. The recovery included both a… Expand
Hair Cell Loss and Regeneration after Exposure to Intense Sound in Neonatal Chicks
TLDR
Hair-cell restoration after severe acoustic injury from intense sound exposure in the neonatal ear is demonstrated and can be recognized by the disorganization of hair cells in the previously injured area. Expand
Hair cell regeneration after streptomycin toxicity in the avian vestibular epithelium
TLDR
The results show that the chicken vestibular sensory epithelium is capable of regenerating hair cells after severe damage, and the epithelia is incapable of complete anatomical recovery. Expand
Hair cell damage produced by acoustic trauma in the chick cochlea
TLDR
Results suggest that developmental changes in the location and extent of hair cell damage depend on the effective stimulus intensity reaching the cochlea, rather than on alterations in the frequency coding of the hair cells. Expand
...
1
2
3
4
5
...