Hair Cell Toxicity in Anti-cancer Drugs: Evaluating an Anti-cancer Drug Library for Independent and Synergistic Toxic Effects on Hair Cells Using the Zebrafish Lateral Line

@article{Hirose2011HairCT,
  title={Hair Cell Toxicity in Anti-cancer Drugs: Evaluating an Anti-cancer Drug Library for Independent and Synergistic Toxic Effects on Hair Cells Using the Zebrafish Lateral Line},
  author={Yoshinobu Hirose and Julian A Simon and Henry C. Ou},
  journal={Journal of the Association for Research in Otolaryngology},
  year={2011},
  volume={12},
  pages={719-728}
}
Inner ear hair cell loss is the most common pathology seen after ototoxic drug injury. While certain drugs such as aminoglycosides and cisplatin are well-known to have dramatic ototoxic effects, it is probable that there are other drugs that cause occult degrees of hair cell loss and lesser degrees of hearing loss. Anti-cancer drugs are particularly strong candidates due to their general cytotoxicity. We have screened a library of 88 anti-cancer drugs (National Cancer Institute Approved… CONTINUE READING

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The zebrafish book: a guide for the laboratory use of zebrafish (Danio rerio)

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