Hair Cell Death in the Avian Basilar Papilla: Characterization of the in vitro Model and Caspase Activation

@article{Cheng2002HairCD,
  title={Hair Cell Death in the Avian Basilar Papilla: Characterization of the in vitro Model and Caspase Activation},
  author={Alan G Cheng and Lisa L Cunningham and Edwin W. Rubel},
  journal={Journal of the Association for Research in Otolaryngology},
  year={2002},
  volume={4},
  pages={91-105}
}
Caspases are a family of proteases that have been implicated as key mediators of cell death. Although nonspecific inhibition of caspase activation has been reported to prevent mammalian sensory hair cell death, the exact roles of individual caspases during hair cell death are unclear. In other systems, the activation of initiator caspases, such as caspase-8 and caspase-9, can lead to the activation of the effector caspase-3. We have begun to systematically characterize hair cell death in an in… CONTINUE READING

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