Haemostatic and metabolic impact of estradiol pills and drospirenone-containing ethinylestradiol pills vs. levonorgestrel-containing ethinylestradiol pills: A literature review

@article{Lete2015HaemostaticAM,
  title={Haemostatic and metabolic impact of estradiol pills and drospirenone-containing ethinylestradiol pills vs. levonorgestrel-containing ethinylestradiol pills: A literature review},
  author={I{\~n}aki Lete and Nathalie Chabbert-Buffet and Christian Georges Jamin and Stefano Lello and Paloma Lobo and Rossella Elena Nappi and Axelle Pintiaux},
  journal={The European Journal of Contraception \& Reproductive Health Care},
  year={2015},
  volume={20},
  pages={329 - 343}
}
Abstract Objective Since its introduction 50 years ago, the contraceptive pill has continuously evolved to decrease the risk of venous thromboembolism (VTE) associated with its use. An increased risk of VTE still remains, however. Other concerns, such as effects on lipid and carbohydrate metabolism, have also been reported. In this study we compared two reference combined oral contraceptives (COCs) containing ethinylestradiol (EE)/levonorgestrel (LNG) and EE/drospirenone (DRSP) with COCs… 

Metabolic and laboratory effects of a progestin-only pill containing drospirenone 4 mg in comparison to desogestrel 75 µg: a double-blind, double-dummy, prospective, randomised study

  • S. PalaciosE. ColliP. Regidor
  • Medicine, Biology
    The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception
  • 2021
The results confirm the beneficial properties of the drospirenone-only pill on a variety of metabolic parameters and on coagulatory parameters, and there was no impact on hemostasis.

Pharmacodynamics of combined estrogen-progestin oral contraceptives: 2. effects on hemostasis

ABSTRACT Introduction: The pharmacodynamic effects of various combined oral estrogen-progestin combinations (COC) are examined for their components alone or in the various combined formulations.

The paradigm of norgestimate: a third-generation testosterone-derivative progestin with a peripheral anti-androgenic activity and the lowest risk of venous thromboembolism

A narrative review of the available data on the pharmacotherapy of NGM in combined hormonal contraceptives (CHCs) in terms of contraceptive efficacy, venous thromboembolism risk, safety, tolerability and bleeding patterns is reviewed.

Estradiol in non-oral hormonal contraception: a “long and winding road”

A recent observational study of a cohort of more than 50,000 new COC users indicates, though with important limitations of real-world data, that the risk of venous thromboembolism (VTE) andother cardiovascular events is similar andpossibly lower with the use of E2 containing pills if compared with EE.

Health Status Is Affected, and Phase I/II Biotransformation Activity Altered in Young Women Using Oral Contraceptives Containing Drospirenone/Ethinyl Estradiol

COCs containing DRSP/EE may, therefore, adversely affect health status and disturb the balance between phase I and II biotransformation reactions, which may be mediated by oxidative stress.

Prospective controlled cohort study on the safety of a monophasic oral contraceptive containing nomegestrol acetate (2.5mg) and 17β-oestradiol (1.5mg) (PRO-E2 study): risk of venous and arterial thromboembolism

  • S. ReedC. Koro K. Heinemann
  • Medicine
    The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception
  • 2021
NOMAC-E2 use was not associated with a higher risk of VTE or ATE compared with COCLNG, and the risk of all VTE and ATE was not higher in NOMAC/E2 users compared withCOCL NG.

A novel estetrol-containing combined oral contraceptive: European expert panel review

The E4-DRSP combination provided effective contraception with good cycle control, characterised by a predictable regular bleeding pattern and minimal unscheduled bleeding, together with a good safety profile, and was associated with high user satisfaction, well-being, and minimal changes in body weight.

Body composition and psychological improvement in healthy premenopausal women assuming the oral contraceptive containing micronized estradiol (E2) and nomegestrol acetate (NOMAC)

  • M. NeriM. E. Malune A. Paoletti
  • Medicine
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • 2017
The study suggests that E2/NOMAC is devoid of negative effects on AI and BC, with additional benefits on PS and dysmenorrhea.

Estradiol in hormonal contraception: real evolution or just same old wine in a new bottle?

  • G. GrandiF. FacchinettiJ. Bitzer
  • Medicine, Biology
    The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception
  • 2017
The International Active Surveillance study ‘Safety of Contraceptives: role of Estrogens’ (INAS-SCORE) investigated the cardiovascular risks and the effectiveness associated with the use of the CHC containing E2V/DNG compared to other EE-based ones in a routine clinical setting.

Oral Contraceptives and Venous Thromboembolism: Focus on Testing that May Enable Prediction and Assessment of the Risk.

Specific attention will be given to the endogenous thrombin potential-based activated protein C resistance, a test aiming at assessing the thrombogenicity induced by hormonal therapies and inherited or acquiredThrombophilia.

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    The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception
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