Haemostasis and thrombosis: an overview

  title={Haemostasis and thrombosis: an overview},
  author={H. Rasche},
  journal={European Heart Journal Supplements},
  • H. Rasche
  • Published 1 December 2001
  • Medicine
  • European Heart Journal Supplements
Physiology of haemostasis
Pitfalls in the hemostatic management of a liver transplantation
A case is presented that highlights some of the more challenging diagnostic and management decisions in liver transplantation and presents a safe and carefully structured approach to hyperfibrinolysis in liver transplants.
Global coagulation assays in hypercoagulable states
A review of the use and limitations of global coagulation assays in healthy controls as well as hypercoagulable conditions is provided.
This thesis cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder(s).
A mathematical model to quantify the effects of platelet count, shear rate, and injury size on the initiation of blood coagulation under venous flow conditions
A reduced one-equation model of thrombin distribution is derived from the previous model under simplifying hypotheses and it is used to determine the conditions of clotting initiation on the platelet count, the shear rate, and the plasma composition.
Determining possible thrombus sites in an extracorporeal device, using computational fluid dynamics-derived relative residence time
The sensitivity of each parameter and the specific mechanical forces are explained, before the optimal indicator of thrombosis risk is outlined and the predicted thrombus sites compare well with evidence collected from explanted devices.
Adverse Drug Reactions and Cutaneous Manifestations Associated With Anticoagulation
This review provides dermatologists with a framework for early diagnosis and management of patients with drug reactions to anticoagulants and alerts them to potential bleeding complications associated with minor procedures.
Control of the blood-polymer interface by plasma treatment.
The physical and chemical modification of the surface is theoretically favorable to the interaction of the polymer with the blood and its components, by means of interfacial tension reduction, polarity increase, cleaning, ordering of molecular chains, functionalization, and stabilization effects.


Adhesive interactions in hemostasis.
Adhesion molecules and adhesive interactions play a critical role in the process of hemostasis, and the interactions between platelets and exposed collagen in the damaged vessel wall, plasma and platelet von Willebrand factor, and plasma and Platelet fibrinogen can all be considered 'adhesive interactions'.
Vascular-bed--specific hemostasis and hypercoagulable states.
The extrinsic pathway of blood coagulation is initiated when blood is exposed to non-vascular-cell–bound tissue factor in the subendothelial space and activates factors IX and X of the intrinsic and common coagulated pathways, respectively.
Hemostatic risk factors and arterial thrombotic disease.
Pathologic studies of coronary arteries in acute MI suggest that the acute thrombosis likely involves activation of both platelets and the coagulation system.
Mechanical factors affecting hemostasis and thrombosis.
Prosthesis-induced hemolysis: mechanisms and quantification of shear stress.
Understanding of how red blood cells can be damaged by the turbulent flow fields associated with current prosthetic mechanical heart valve designs improves, but continued advances in understanding the hemolytic complications associated with different valve designs will depend on the development of more sophisticated in vitro quantitative engineering techniques.
Platelet function inhibitors in the Year 2000.
The mechanism of action and clinical utility of the currently available platelet function inhibitors are addressed.
The Haemostatic Balance – Astrup Revisited
The overall theme of this review, apart from an insight into various aspects of the haemostatic balance, is that blood has a strong tendency to clot when tissue is damaged, and the intact vasculature requires major anticoagulant systems to prevent clots adhering to and stabilising in the vasculatures.
Role of endothelium in thrombosis and hemostasis.
Endothelium produces and secretes von Willebrand factor, which mediates platelet adhesion and shear-stress-induced aggregation, and releases prostacyclin and nitric oxide, potent inhibitors of platelet and monocyte activation and vasodilators.
Genetic susceptibility to venous thrombosis.
Conditions involving a genetic predisposition to venous thrombosis, one of the leading causes of mortality and morbidity, increases from 1 per 100,000 during childhood to 1 every 100 in old age, is discussed.
High prevalence of hypercoagulable states in patients with recurrent thrombosis of mechanical heart valves.
Investigation of the frequency of hypercoagulable states in patients with MHV who had recurrent thrombosis at least twice after valve implantation found that these states are highly prevalent, and surgical replacement of the MHV with a bioprosthesis should be considered.