Haemophilus influenzae uses the surface protein E to acquire human plasminogen and to evade innate immunity.

@article{Barthel2012HaemophilusIU,
  title={Haemophilus influenzae uses the surface protein E to acquire human plasminogen and to evade innate immunity.},
  author={Diana Barthel and Birendra Bob N. Singh and Kristian Riesbeck and Peter F Zipfel},
  journal={Journal of immunology},
  year={2012},
  volume={188 1},
  pages={379-85}
}
Pathogenic microbes acquire the human plasma protein plasminogen to their surface. In this article, we characterize binding of this important coagulation regulator to the respiratory pathogen nontypeable Haemophilus influenzae and identify the Haemophilus surface protein E (PE) as a new plasminogen-binding protein. Plasminogen binds dose dependently to intact bacteria and to purified PE. The plasminogen-PE interaction is mediated by lysine residues and is also affected by ionic strength. The H… CONTINUE READING
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