Haemophilus influenzae responds to glucocorticoids used in asthma therapy by modulation of biofilm formation and antibiotic resistance

@inproceedings{Earl2015HaemophilusIR,
  title={Haemophilus influenzae responds to glucocorticoids used in asthma therapy by modulation of biofilm formation and antibiotic resistance},
  author={Christan Earl and Teh Wooi Keong and Shi-Qi An and Sarah Murdoch and Yvonne McCarthy and J. Gonz{\'a}lez Garmendia and Joseph Ward and John Maxwell Dow and Liang Yang and George A. O’Toole and Robert Patrick Ryan},
  booktitle={EMBO molecular medicine},
  year={2015}
}
Glucocorticosteroids are used as a main treatment to reduce airway inflammation in people with asthma who suffer from neutrophilic airway inflammation, a condition frequently associated with Haemophilus influenzae colonization. Here we show that glucocorticosteroids have a direct influence on the behavior of H. influenzae that may account for associated difficulties with therapy. Using a mouse model of infection, we show that corticosteroid treatment promotes H. influenzae persistence… CONTINUE READING
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