Haemophilus influenzae Type b Conjugate Vaccine with a Synthetic Capsular Polysaccharide Antigen : Chemical View

@inproceedings{Bencomo2008HaemophilusIT,
  title={Haemophilus influenzae Type b Conjugate Vaccine with a Synthetic Capsular Polysaccharide Antigen : Chemical View},
  author={Vicente V{\'e}rez Bencomo and Ren{\'e} Roy and Maria C. Rodr{\'i}guez and A J Santini Villar and Violeta Fern{\'a}ndez-Santana and Ernesto Garc{\'i}a and Yury Vald{\'e}s and L{\'a}zaro E. Heynngnezz and Iv{\'a}n Arenas Sosa and Ernesto Medina},
  year={2008}
}
Glycoconjugate vaccines containing capsular polysaccharides were developed in the last 20 years against Haemophilus influenzae type b. They provided effective prophylaxis against meningitis and pneumonia, especially amongst infants. Despite recent advancements in synthetic carbohydrate chemistry, the technology for using a synthetic antigen in a commercial vaccine remains a formidable challenge. Major chemical problems to be solved and the strategies employed to produce the first vaccine… 
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