Haemophilus ducreyi targets Src family protein tyrosine kinases to inhibit phagocytic signaling.

@article{Mock2005HaemophilusDT,
  title={Haemophilus ducreyi targets Src family protein tyrosine kinases to inhibit phagocytic signaling.},
  author={Jason R Mock and Merja Vakevainen and Kaiping Deng and J. L. Latimer and Jennifer A. Young and Nicolai S. C. van Oers and Steven M Greenberg and Eric J. Hansen},
  journal={Infection and immunity},
  year={2005},
  volume={73 12},
  pages={7808-16}
}
Haemophilus ducreyi, the etiologic agent of the sexually transmitted disease chancroid, has been shown to inhibit phagocytosis of both itself and secondary targets in vitro. Immunodepletion of LspA proteins from H. ducreyi culture supernatant fluid abolished this inhibitory effect, indicating that the LspA proteins are necessary for the inhibition of phagocytosis by H. ducreyi. Fluorescence microscopy revealed that macrophages incubated with wild-type H. ducreyi, but not with a lspA1 lspA2… CONTINUE READING
11 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

Similar Papers

Loading similar papers…