Haemonchus contortus Acetylcholine Receptors of the DEG-3 Subfamily and Their Role in Sensitivity to Monepantel

@article{Rufener2009HaemonchusCA,
  title={Haemonchus contortus Acetylcholine Receptors of the DEG-3 Subfamily and Their Role in Sensitivity to Monepantel},
  author={Lucien Rufener and Pascal M{\"a}ser and Isabel Roditi and R. S. Kaminsky},
  journal={PLoS Pathogens},
  year={2009},
  volume={5},
  pages={1363 - 1367}
}
Gastro-intestinal nematodes in ruminants, especially Haemonchus contortus, are a global threat to sheep and cattle farming. The emergence of drug resistance, and even multi-drug resistance to the currently available classes of broad spectrum anthelmintics, further stresses the need for new drugs active against gastro-intestinal nematodes. A novel chemical class of synthetic anthelmintics, the Amino-Acetonitrile Derivatives (AADs), was recently discovered and the drug candidate AAD-1566… CONTINUE READING
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Identification of the amino-acetonitrile derivative monepantel (AAD 1566) as a new anthelmintic drug development candidate

  • R Kaminsky, N Gauvry, S Schorderet Weber, T Skripsky, J Bouvier
  • Parasitol Res
  • 2008
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