Haemolytic and cytotoxic action of latarcin Ltc2a.

  title={Haemolytic and cytotoxic action of latarcin Ltc2a.},
  author={Olga V Vorontsova and Natalya S. Egorova and Alexander S. Arseniev and Alexey V. Feofanov},
  volume={93 2},
Activity and action mechanisms of latarcin 2a (Ltc2a), an antimicrobial peptide from the venom of the spider Lachesana tarabaevi (Zodariidae), were studied in vitro on human cells. Cytotoxicity of Ltc2a for erythrocytes (EC(50) = 3.4 μM), leukocytes (EC(50) = 19.5 μM) and erythroleukemia K562 cells (EC(50) = 3.3 μM) has been found to be primary related to plasma membrane destabilization. Using fluorescently labeled Ltc2a, three common features are found for erythrocytes and K562 cells… CONTINUE READING


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  • S. A. Kozlov, A. A. Vassilevski, A. V. Feofanov, A. Y. Surovoy, D. V. Karpunin, E. V. Grishin
  • antimicrobial and cytolytic peptides from the…
  • 2006
Highly Influential
9 Excerpts


  • L. Cruz-Chamorro, M. A. Puertollano
  • Puertollano, G.A. de Cienfuegos, M.A. de Pablo…
  • 2006
Highly Influential
12 Excerpts


  • A. Risso, E. Braidot, +6 authors P. Bernardi
  • an antibiotic peptide of innate immunity, induces…
  • 2002
Highly Influential
12 Excerpts

Epand, Osmotically induced membrane tension modulates membrane permeabilization by class L O.V

  • I. V. Polozov, G. M. Anantharamaiah, R.M.J.P. Segrest
  • Vorontsova et al. / Biochimie
  • 2011


  • D. V. Krysko, T. Vanden Berghe
  • D’Herde, P. Vandenabeele, Apoptosis and necrosis…
  • 2008
1 Excerpt

Kinetics of dye ef fl ux and lipid fl ipfl op induced by deltalysin in phosphatidylcholine vesicles and the mechanism of graded release by amphipathic , alpha - helical peptides

  • A. Pokorny, P. F. Almeida
  • Biochemistry
  • 2008

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