Haemolytic and cytotoxic action of latarcin Ltc2a.

@article{Vorontsova2011HaemolyticAC,
  title={Haemolytic and cytotoxic action of latarcin Ltc2a.},
  author={Olga V Vorontsova and Natalya S. Egorova and Alexander S. Arseniev and Alexey V. Feofanov},
  journal={Biochimie},
  year={2011},
  volume={93 2},
  pages={227-41}
}
Activity and action mechanisms of latarcin 2a (Ltc2a), an antimicrobial peptide from the venom of the spider Lachesana tarabaevi (Zodariidae), were studied in vitro on human cells. Cytotoxicity of Ltc2a for erythrocytes (EC(50) = 3.4 μM), leukocytes (EC(50) = 19.5 μM) and erythroleukemia K562 cells (EC(50) = 3.3 μM) has been found to be primary related to plasma membrane destabilization. Using fluorescently labeled Ltc2a, three common features are found for erythrocytes and K562 cells… CONTINUE READING

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