Haemoglobin-based blood substitutes and sepsis.

  title={Haemoglobin-based blood substitutes and sepsis.},
  author={Elwyn Griffiths and A. Cortes Cortes and Nigel Gilbert and Philip Stevenson and Shaun Macdonald and Daile Pepper},
  volume={345 8943},
An important concern that has received little attention is the possible increased susceptibility to bacterial infections of patients infused with cell-free haemoglobin-based blood substitutes. We show that pyridoxalated polymerised human haemoglobin promotes fulminating Escherichia coli septicaemia in mice, which draws attention to the potential danger of… CONTINUE READING