Haemoglobin C protects against clinical Plasmodium falciparum malaria

@article{Modiano2001HaemoglobinCP,
  title={Haemoglobin C protects against clinical Plasmodium falciparum malaria},
  author={David Laurence Modiano and Gaia Luoni and Bienvenu Sodiomon Sirima and Jacques Simpore and Federica Verra and Amadou M Konat{\'e} and Elena Rastrelli and Anna Olivieri and Carlo Calissano and Giacomo Maria Paganotti and Leila E D'Urbano and Issa Sanou and Alphonse Sawadogo and Guido Modiano and Mario Coluzzi},
  journal={Nature},
  year={2001},
  volume={414},
  pages={305-308}
}
Haemoglobin C (HbC; β6Glu → Lys) is common in malarious areas of West Africa, especially in Burkina Faso. Conclusive evidence exists on the protective role against severe malaria of haemoglobin S (HbS; β6Glu → Val) heterozygosity, whereas conflicting results for the HbC trait have been reported and no epidemiological data exist on the possible role of the HbCC genotype. In vitro studies suggested that HbCC erythrocytes fail to support the growth of P. falciparum but HbC homozygotes with high P… CONTINUE READING
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