Haemodynamics determined by a genetic programme govern asymmetric development of the aortic arch

@article{Yashiro2007HaemodynamicsDB,
  title={Haemodynamics determined by a genetic programme govern asymmetric development of the aortic arch},
  author={Kurato Yashiro and Hidetaka Shiratori and Hiroshi Hamada},
  journal={Nature},
  year={2007},
  volume={450},
  pages={285-288}
}
Laterality of the internal organs of vertebrates is determined by asymmetric Nodal signalling in the lateral plate mesoderm. A deficiency of such signalling results in heterotaxia syndrome, characterized by anomalous laterality of visceral organs and complex congenital heart conditions. Pitx2, the transcription factor induced by the Nodal signal, regulates left–right asymmetric morphogenesis. The cellular and molecular bases of asymmetric morphogenesis remain largely unknown, however. Here we… CONTINUE READING
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A modifier of the del22q11 (DiGeorge) syndrome? Nature Med

Stalmans, I. et al. Vegf
  • 9, 173–182
  • 2003