Haemodynamic effects of prenaterol and cardiac glycosides in patients with recent myocardial infarction

  title={Haemodynamic effects of prenaterol and cardiac glycosides in patients with recent myocardial infarction},
  author={Patrik Bostr{\"o}m and J. H. Andersson and B. W. Johansson and Bo Lilja and Jan I. Thorell and K Tidf{\"a}lt and S. Westerling},
  journal={European Journal of Clinical Investigation},
Abstract. Prenalterol was given to twenty five patients with acute myocardial infarction. Thirteen patients (group B) had signs of cardiac decompensation while twelve (group A) had not. Ejection fraction was determined with 99mTc‐labelled red blood cells before and after prenalterol (50 μg kg‐1 body weight), intravenously. In group B this procedure was repeated after digitalization 2 days later. The ejection fraction increased significantly in group A after prenalterol injection. In group B… 
Digitalis and heart failure: Does digitalis really produce beneficial effects through a positive inotropic action?
The statement that digitalis is essentially an inotropic agent seems restrictive; its definition should reflect the favorable effects obtained in some cases of congestive heart failure rather than its various and contrasting underlying mechanisms of action.
Effects of digitalis on the normal and the failing heart.
  • E. Braunwald
  • Medicine
    Journal of the American College of Cardiology
  • 1985
It has now been established that cardiac glycosides cause arteriolar and venous constriction in a variety of mammalian species including human beings, and that this vasoconstriction involves the coronary vascular bed as well, but it is believed that these actions are not responsible for any beneficial clinical effect.
The use of digitalis for the treatment of congestive heart failure: A tale of its decline and resurrection
  • F. Marcus
  • Medicine
    Cardiovascular Drugs and Therapy
  • 2005
It is concluded that digitalis is a mild inotropic agent that is still a primary drug for the treatment of mild to moderate acute or chronic left ventricular failure.
Effect of xamoterol on exercise capacity and left ventricular function in angina pectoris and in dilated cardiomyopathy
Effect of xamoterol on exercise capacity and left ventricular function in angina pectoris and in dilated cardiomyopathy is studied.
Congestive Heart Failure in the Elderly
Treatment is now directed against the individual components of the symptom complex and not the antecedent disease and age-related changes that produce CHF, and additional research is needed before treatment of CHF will be more effective.
Digitalis. Mechanisms of action and clinical use.
  • T. Smith
  • Medicine
    The New England journal of medicine
  • 1988


Haemodynamic effects of prenalterol in patients with coronary heart disease.
Results indicate that prenalterol enhances the contractile state of the myocardium without altering heart rate, and suggest that the drug could be of value in the management of patients with coronary heart disease, who have impaired left ventricular function.
Clinical results with prenalterol in patients with heart failure.
Patients with chronic congestive heart failure after myocardial infraction, valvular surgery, and congestive cardiomyopathy are studied, and PNL may be of value for long-term CHF treatment in addition to conventional therapy.
Hemodynamic actions of prenalterol in severe congestive heart failure due to chronic coronary disease.
PN produced considerable improvement of depressed cardiocirculatory performance without untoward effects and thereby appears a valuable new cardiotonic in the clinical management of severe low output ventricular dysfunction.
The effects of intravenous prenalterol on ventricular performance, as assessed by radionuclide ventriculography, in patients with ischaemic heart disease.
The increase in systolic blood pressure, and therefore cardiac afterload brought about by prenalterol may limit ventricular response, and the response might be enhanced by the addition of vasodilator therapy.
A comparative study of cardioselective beta-blockade and diazepam in patients wtih acute myocardial infarction and tachycardia.
The drug treatment elicited no reduction of infarct size, as judged from enzyme levels, degree of reduction of ST elevation, or physical exercise capacity, and a beneficial effect on mortality among the patients whose treatment started early after onset of symptoms is supported.
Hemodynamic effects Of Dixogin in acute myocardial infarction
It is concluded that Digoxin treatment during AMI can favourably affect the circulatory conditions primarily in cases with a moderate left ventricular failure, and the beneficial effects of the drug seemed to be less evident when administered to patients with almost normal pump function or with extreme degrees of left Ventricular failure.
Hemodynamic effects of intravenous prenalterol in severe heart failure.
Intravenous prenalterol produces hemodynamic improvement in patients with a chronic severe low output state but may be associated with increased ventricular ectopic activity.
Evaluation of digitalis in cardiac failure.
In this study both intravenous ouabain and maintenance treatment with oral digoxin exerted a modest positive inotropic effect in patients with cardiac failure in sinus rhythm, however, the haemodynamic benefit was manifest only during exertion.
Determination of prenalterol in plasma and in urine by gas-liquid chromatography.
A description is given of a gas-liquid chromatographic method for the quantitative determination of unchanged prenalterol in plasma and for the total (free and conjugated) prenalterol in urine. After
Regional Ejection Fraction A Quantitative Radionuclide Index of Regional Left Ventricular Performance
It is concluded that the left ventricular regional ejection fraction provides a reliable quantitative assessment of regionalleft ventricular performance.