Haemodynamic effects of prenaterol and cardiac glycosides in patients with recent myocardial infarction

@article{Bostrm1984HaemodynamicEO,
  title={Haemodynamic effects of prenaterol and cardiac glycosides in patients with recent myocardial infarction},
  author={Patrik Bostr{\"o}m and J. H. Andersson and B. W. Johansson and Bo Lilja and Jan I. Thorell and K Tidf{\"a}lt and S. Westerling},
  journal={European Journal of Clinical Investigation},
  year={1984},
  volume={14}
}
Abstract. Prenalterol was given to twenty five patients with acute myocardial infarction. Thirteen patients (group B) had signs of cardiac decompensation while twelve (group A) had not. Ejection fraction was determined with 99mTc‐labelled red blood cells before and after prenalterol (50 μg kg‐1 body weight), intravenously. In group B this procedure was repeated after digitalization 2 days later. The ejection fraction increased significantly in group A after prenalterol injection. In group B… 
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TLDR
Results indicate that prenalterol enhances the contractile state of the myocardium without altering heart rate, and suggest that the drug could be of value in the management of patients with coronary heart disease, who have impaired left ventricular function.
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Patients with chronic congestive heart failure after myocardial infraction, valvular surgery, and congestive cardiomyopathy are studied, and PNL may be of value for long-term CHF treatment in addition to conventional therapy.
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PN produced considerable improvement of depressed cardiocirculatory performance without untoward effects and thereby appears a valuable new cardiotonic in the clinical management of severe low output ventricular dysfunction.
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The increase in systolic blood pressure, and therefore cardiac afterload brought about by prenalterol may limit ventricular response, and the response might be enhanced by the addition of vasodilator therapy.
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It is concluded that Digoxin treatment during AMI can favourably affect the circulatory conditions primarily in cases with a moderate left ventricular failure, and the beneficial effects of the drug seemed to be less evident when administered to patients with almost normal pump function or with extreme degrees of left Ventricular failure.
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