Haemodynamic effects of intracoronary pyruvate in patients with congestive heart failure: an open study

@article{Hermann1999HaemodynamicEO,
  title={Haemodynamic effects of intracoronary pyruvate in patients with congestive heart failure: an open study},
  author={H P Hermann and Burkert Pieske and Eberhard Schwarzm{\"o}ller and Joseph Keul and Hanj{\"o}rg Just and Gerd Hasenfuss},
  journal={The Lancet},
  year={1999},
  volume={353},
  pages={1321-1323}
}
BACKGROUND Pyruvate, as an intermediate in the Krebs cycle, is an important source of energy for myocardium and improves contractility of normal, hypoxic, and postischaemic animal myocardium. We investigated the effect of intracoronary pyruvate in patients with congestive heart failure. METHODS Haemodynamic measurements were done in eight patients with dilated cardiomyopathy after two 15 min infusions of pyruvate into the left main coronary artery and after saline washout of pyruvate… Expand

Paper Mentions

Interventional Clinical Trial
Pyruvate is an intermediate of energy metabolism and was shown to possess pronounced positive inotropic effects in vitro and in vivo without altering myocardial oxygen consumption… Expand
ConditionsAcute Myocardial Infarction, Heart Failure, Shock, Cardiogenic
InterventionDrug
Intracoronary pyruvate in cardiogenic shock as an adjunctive therapy to catecholamines and intra-aortic balloon pump shows beneficial effects on hemodynamics
TLDR
Intracoronary pyruvate might show beneficial effects in severe acute heart failure in addition to treatment with catecholamines and IABP and should be further investigated in randomized controlled trials. Expand
Influence of Pyruvate on Contractile Performance and Ca2+ Cycling in Isolated Failing Human Myocardium
TLDR
The present findings indicate that pyruvate improves contractile performance of failing human myocardium by increasing intracellular Ca2+ transients as well as myofilament Ca2+, and the former seem to result from increased SR Ca2- accumulation and release, the latter from increased intrACEllular pH. Expand
Potentiation of beta-adrenergic inotropic response by pyruvate in failing human myocardium.
TLDR
A combination of pyruvate and beta-adrenergic stimulation may be of therapeutic value in acute heart failure by reducing the concentrations of potential deleterious catecholamines that are currently necessary to maintain adequate tissue perfusion. Expand
Energetic Stimulation of the Heart
  • H. Hermann
  • Medicine
  • Cardiovascular Drugs and Therapy
  • 2004
TLDR
Energetic stimulation with pyruvate could be a new promising approach to the treatment of acute heart failure, if conventional therapy fails. Expand
The study of myocardial metabolism and its role in the pathophysiology of early diabetic cardiomyopathy
TLDR
It is demonstrated that microvascular disease plays little role in the development of impaired cardiac energetics in young patients with uncomplicated type 1 diabetes and an increase in left ventricular torsion in these patients with normal ejection fraction is shown. Expand
Cardioprotective effect of N-methylnicotinamide salt of pyruvate in experimental model of cardiac hypoxia.
TLDR
This study demonstrated that administration of MNA pyruvate prior to a hypoxia-induced cardiac event was cardioprotective and did not cause hypernatremia in contrast to sodium pyruVate. Expand
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TLDR
It is suggested that chronic manipulation of myocardial substrate oxidation toward greater carbohydrate oxidation and less fatty acid oxidation may improve ventricular performance and slow the progression of left ventricular dysfunction in heart failure patients. Expand
The intermediary metabolite pyruvate attenuates stunning and reduces infarct size in in vivo porcine myocardium.
TLDR
It is suggested that pyruvate attenuates stunning and decreases myocardial infarction in vivo in part by reduction of reperfusion injury, and should be considered when designing the optimal therapeutic strategies for limiting myCardial ischemia-reperfusion Injury. Expand
Post-Ischemic Treatment with Dipyruvyl-Acetyl-Glycerol Decreases Myocardial Infarct Size in the Pig
TLDR
An intravenous infusion of DPAG safely increases arterial pyruvate concentration and reduces myocardial infarct size following myocardian ischemia in an anesthetized open-chest pig model of ischemIA-reperfusion injury. Expand
Pyruvate/dichloroacetate supply during reperfusion accelerates recovery of cardiac energetics and improves mechanical function following cardioplegic arrest.
  • R. Smolenski, M. Amrani, +5 authors M. Yacoub
  • Medicine
  • European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • 2001
TLDR
The administration of pyruvate and dichloroacetate improves the recovery of mechanical function following hypothermic ischaemia and accelerated restoration of the energy equilibrium in the initial phase of reperfusion may underlie the metabolic mechanism of this effect. Expand
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