Haemodynamic effects of intracoronary pyruvate in patients with congestive heart failure: an open study

  title={Haemodynamic effects of intracoronary pyruvate in patients with congestive heart failure: an open study},
  author={H. Hermann and B. Pieske and Eberhard Schwarzm{\"o}ller and J. Keul and G. Hasenfu{\ss}},
  journal={The Lancet},
  • H. Hermann, B. Pieske, +2 authors G. Hasenfuß
  • Published 1999
  • Medicine
  • The Lancet
  • BACKGROUND Pyruvate, as an intermediate in the Krebs cycle, is an important source of energy for myocardium and improves contractility of normal, hypoxic, and postischaemic animal myocardium. We investigated the effect of intracoronary pyruvate in patients with congestive heart failure. METHODS Haemodynamic measurements were done in eight patients with dilated cardiomyopathy after two 15 min infusions of pyruvate into the left main coronary artery and after saline washout of pyruvate… CONTINUE READING
    110 Citations

    Paper Mentions

    Pyruvate is an intermediate of energy metabolism and was shown to possess pronounced positive inotropic effects in vitro and in vivo without altering myocardial oxygen consumption… Expand
    ConditionsAcute Myocardial Infarction, Heart Failure, Shock, Cardiogenic
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