Haemodynamic effects of an angiotensin-converting enzyme inhibitor and angiotensin receptor antagonist during hypovolaemia in the anaesthetized pig.

@article{Ryckwaert2002HaemodynamicEO,
  title={Haemodynamic effects of an angiotensin-converting enzyme inhibitor and angiotensin receptor antagonist during hypovolaemia in the anaesthetized pig.},
  author={Fr{\'e}d{\'e}rique Ryckwaert and P H Colson and E. Andre and P-F Perrigault and Gilles Guillon and Claude E Barberis},
  journal={British journal of anaesthesia},
  year={2002},
  volume={89 4},
  pages={599-604}
}
BACKGROUND Renin-angiotensin system antagonists, either angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor (AT(1)) antagonists, may interfere with regulation of arterial pressure during anaesthesia. This study aimed to compare the haemodynamic profile of anaesthetized pigs, which were subjected to haemorrhage in the presence of the ACE inhibitor enalaprilat or the AT(1) antagonist valsartan. METHODS Thirty-six pigs were assigned randomly to placebo, enalaprilat or… CONTINUE READING