Haemodynamic and hormonal effects of adrenomedullin in patients with pulmonary hypertension.

@article{Nagaya2000HaemodynamicAH,
  title={Haemodynamic and hormonal effects of adrenomedullin in patients with pulmonary hypertension.},
  author={Noritoshi Nagaya and Toshio Nishikimi and Masaaki Uematsu and Toru Satoh and Hideo Oya and Shingo Kyotani and Fumio Sakamaki and Kazuyuki Ueno and Norifumi Nakanishi and Kunio Miyatake and Kenji Kangawa},
  journal={Heart},
  year={2000},
  volume={84 6},
  pages={653-8}
}
OBJECTIVE To investigate whether infusion of adrenomedullin, a potent vasorelaxant peptide, has beneficial haemodynamic and hormonal effects in patients with pulmonary hypertension. PATIENTS AND DESIGN The haemodynamic and hormonal responses to intravenous infusion of adrenomedullin (0.05 microgram/kg/min) or placebo were examined in 13 patients with precapillary pulmonary hypertension. RESULTS Infusion of adrenomedullin produced a 44% increase in cardiac index (mean (SD) 1.8 (0.2) to 2.6… CONTINUE READING

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