Haematoporphyrin derivative (Photofrin II) photosensitization of isolated mitochondria: inhibition of ADP/ATP translocator.

@article{Atlante1989HaematoporphyrinD,
  title={Haematoporphyrin derivative (Photofrin II) photosensitization of isolated mitochondria: inhibition of ADP/ATP translocator.},
  author={Anna Atlante and Salvatore Passarella and Ernesto Quagliariello and Giuliana Moreno and Christian Salet},
  journal={Journal of photochemistry and photobiology. B, Biology},
  year={1989},
  volume={4 1},
  pages={35-46}
}
To gain further insight into the mechanism by which irradiation of mitochondria in the presence of haematoporphyrin derivative (Photofrin II) (PF II) causes impairment of mitochondrial oxidative phosphorylation, the rate of ADP/ATP exchange via the ADP/ATP translocator was measured fluorometrically is isolated rat liver mitochondria. In accord with noncompetitive inhibition, PF II photosensitization decreases the maximum rate of exchange Vmax (20.8 and 9.6 nmol ATP effluxed min-1 x mg protein… CONTINUE READING