Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene

@article{Mikkola2003HaematopoieticSC,
  title={Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene},
  author={Hanna Katri Annikki Mikkola and Jenny Klintman and Haidi Yang and Hanno Hock and Thorsten M. Schlaeger and Yuko Fujiwara and Stuart H Orkin},
  journal={Nature},
  year={2003},
  volume={421},
  pages={547-551}
}
The production of blood cells is sustained throughout the lifetime of an individual by haematopoietic stem cells (HSCs). Specification of HSCs from mesoderm during embryonic development requires the stem cell leukaemia SCL/tal-1 gene product. Forced expression of SCL/tal-1 strongly induces blood formation in embryos, indicating that this gene has a dominant role in commitment to haematopoiesis. In the adult haematopoietic system, expression of SCL/tal-1 is enriched in HSCs and multipotent… CONTINUE READING
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