Haematopoietic stem cell transplantation to treat aplastic anaemia.

  title={Haematopoietic stem cell transplantation to treat aplastic anaemia.},
  author={Jos{\'e} Carlos Jaime-P{\'e}rez and Guillermo J Ruiz-Arguelles and David G{\'o}mez-Almaguer},
  journal={Expert opinion on biological therapy},
  volume={5 5},
Aplastic anaemia (AA) consists of pancytopenia and empty bone marrow. Its incidence varies worldwide but predominates in developing countries. Diverse aetiologies are involved, with autoimmunity at the centre of the picture. For the 70% of patients with the severe and very severe forms of AA and who lack a human leukocyte antigen (HLA)-matched sibling, immunosuppressive therapy (IST) is key in treating the disease, with a remission rate close to 70%, an 80-90% 5-year survival rate in responding… CONTINUE READING