Haematopoietic stem cell transplantation for autoimmune diseases

@article{Swart2017HaematopoieticSC,
  title={Haematopoietic stem cell transplantation for autoimmune diseases},
  author={Joost F Swart and Eveline M. Delemarre and Femke van Wijk and Jaap Jan Boelens and J{\"u}rgen H. E. Kuball and Jacob M. van Laar and Nico M Wulffraat},
  journal={Nature Reviews Rheumatology},
  year={2017},
  volume={13},
  pages={244-256}
}
Autologous haematopoietic stem cell transplantation (HSCT) is the only treatment that is able to induce long-term, drug-free and symptom-free remission in several refractory autoimmune rheumatic diseases. Over 3,000 HSCT procedures for rheumatic and nonrheumatic severe autoimmune diseases have been performed worldwide. Specific conditioning regimens are currently used to eradicate the autoreactive immunological memory of patients. Although in vivo immune cell depletion with antithymocyte… Expand
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Haematopoietic stem cell transplants: principles and indications.
TLDR
An overview of autologous and allogeneic haematopoietic stem cell transplantation including disease indications, the individual steps of the procedure and outcome, and highlights achievements in the treatment of autoimmune diseases is provided. Expand
Resetting the T Cell Compartment in Autoimmune Diseases With Autologous Hematopoietic Stem Cell Transplantation: An Update
TLDR
There is currently a knowledge gap regarding the immune response in tissue sites post-aHSCT, as well as disease-specific factors that may determine remission or relapse, and future studies on lymphocyte dynamics and function may pave the way for optimized conditioning regimens with a more individualized approach. Expand
Hematopoietic stem cell transplantation for autoimmune diseases: more than just prolonged immunosuppression
  • A. Tyndall
  • Biology, Medicine
  • Current opinion in hematology
  • 2018
TLDR
For the first time, it has been demonstrated that strategies exist which may permanently reprogram an autoaggressive immune system to one of self-tolerance independent of ongoing immunosuppression. Expand
Application of stem cell transplantation to autoimmune diseases.
TLDR
The aim of HSCT is to 'reset' one's immune system into a naïve and self-tolerant state through immune depletion and regulation, which requires careful patient selection, close collaboration between physicians and expertise of transplant team to ensure optimal outcome. Expand
Thymus Rejuvenation After Autologous Hematopoietic Stem Cell Transplantation in Patients with Autoimmune Diseases
TLDR
Investigation should be made to improve the knowledge about immune mechanisms involved in AHSCT for AD and to unravel biomarkers of post-transplantation outcomes, which are associated with favorable clinical outcomes. Expand
Autologous ATG-free hematopoietic stem cell transplantation for refractory autoimmune rheumatic diseases: a Latin American cohort
TLDR
HSCT is a viable treatment alternative for selected patients with severe therapy-resistant ARDs, as an improvement in disease management and quality of life was documented, and the need remains to elucidate the characteristics of the optimal HSCT candidate, as well as the adequate conditioning regimen when ATG is not available. Expand
Haematopoietic stem cell transplantation in systemic sclerosis
TLDR
Hematopoietic stem cell transplantation should be proposed for carefully selected patients with early rapidly progressive diffuse SSc whose clinical picture portends a poor prognosis for survival, but yet lacks advanced organ involvement. Expand
Haematopoietic stem cell transplantation in paediatric rheumatic disease
TLDR
Careful patient and donor selection, timing of the transplant earlier in the course of disease rather than the ‘last resort’ and choosing the most suitable conditioning regimen for each individual patient are the major factors favouring successful outcome. Expand
Autologous Hematopoietic Stem Cell Transplantation for Autoimmune Diseases: From Mechanistic Insights to Biomarkers
TLDR
AHSCT for AD has entered a new era and researchers of this field should work to identify robust predictive, prognostic, treatment-response biomarkers and to establish new guidelines for immune monitoring studies and combined therapeutic interventions to further improve the AHSCT protocols and their therapeutic efficacy. Expand
Hematopoietic stem cell therapy for autoimmune diseases - Clinical experience and mechanisms.
TLDR
The current role and future perspectives of HSCT in AD are discussed, focusing on recent published clinical and scientific studies and recommendations in the field. Expand
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