Haematopoietic stem cell release is regulated by circadian oscillations

@article{MndezFerrer2008HaematopoieticSC,
  title={Haematopoietic stem cell release is regulated by circadian oscillations},
  author={Sim{\'o}n M{\'e}ndez-Ferrer and Daniel Lucas and Michela Battista and Paul S. Frenette},
  journal={Nature},
  year={2008},
  volume={452},
  pages={442-447}
}
Haematopoietic stem cells (HSCs) circulate in the bloodstream under steady-state conditions, but the mechanisms controlling their physiological trafficking are unknown. Here we show that circulating HSCs and their progenitors exhibit robust circadian fluctuations, peaking 5 h after the initiation of light and reaching a nadir 5 h after darkness. Circadian oscillations are markedly altered when mice are subjected to continuous light or to a ‘jet lag’ (defined as a shift of 12 h). Circulating… 
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References

SHOWING 1-10 OF 58 REFERENCES
Identification of the haematopoietic stem cell niche and control of the niche size
TLDR
It is concluded that SNO cells lining the bone surface function as a key component of the niche to support HSCs, and that BMP signalling through BMPRIA controls the number of H SCs by regulating niche size.
Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide.
TLDR
It is reported that mobilization of HPCs by GCSF coincides in vivo with the cleavage of the N-terminus of the chemokine receptor CXCR4 on H PCs resident in the BM and mobilized into the PB.
G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4
TLDR
It is suggested that manipulation of SDF-1–CXCR4 interactions may be a means with which to control the navigation of progenitors between the BM and blood to improve the outcome of clinical stem cell transplantation.
G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow.
TLDR
Data suggest a model in which G-CSF, through an indirect mechanism, potently inhibits osteoblast activity resulting in decreased CXCL12 expression in the bone marrow, which ultimately leads to HPC mobilization.
Circadian rhythms: mechanisms and therapeutic implications.
TLDR
The rhythmic control of xenobiotic detoxification provides the molecular basis for the dosing time-dependence of drug toxicities and efficacy and can in turn be used in improving or designing chronotherapeutics for the patients who suffer from many of the major human diseases.
Current mechanistic scenarios in hematopoietic stem/progenitor cell mobilization.
TLDR
A full understanding of the directional cues that control the migratory behavior and the fate of stem/progenitor cells once they migrate out of bone marrow will await further experimentation, aiming to bridge the current gaps in knowledge.
...
...